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Kohei Koga Selected Research

(4- (m- Chlorophenylcarbamoyloxy)- 2- butynyl)trimethylammonium Chloride

2/2020Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice.
1/2019Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.
11/2004Intrathecal clonidine inhibits mechanical allodynia via activation of the spinal muscarinic M1 receptor in streptozotocin-induced diabetic mice.

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Kohei Koga Research Topics

Disease

7Chronic Pain
12/2019 - 12/2010
7Pain (Aches)
12/2019 - 12/2010
5Hypersensitivity (Allergy)
02/2020 - 11/2004
4Neuralgia (Stump Neuralgia)
12/2019 - 01/2011
4Inflammation (Inflammations)
12/2019 - 12/2005
3Peripheral Nerve Injuries
10/2014 - 12/2010
3Hyperalgesia
05/2007 - 11/2004
2Pruritus (Itching)
09/2013 - 06/2011
1Tobacco Use Disorder (Nicotine Dependence)
12/2021
1Synucleinopathies
08/2020
1Status Epilepticus (Complex Partial Status Epilepticus)
08/2020
1Seizures (Absence Seizure)
08/2020
1Neuroinflammatory Diseases
01/2019
1Fragile X Syndrome (Martin Bell Syndrome)
01/2018
1Sleep Initiation and Maintenance Disorders (Insomnia)
01/2017
1Irritable Bowel Syndrome (Syndrome, Irritable Bowel)
06/2014

Drug/Important Bio-Agent (IBA)

4Muscarinic M1 ReceptorIBA
02/2020 - 11/2004
4Freund's AdjuvantIBA
01/2019 - 12/2005
4Analgesics (Analgesic Drugs)IBA
01/2018 - 01/2011
3(4- (m- Chlorophenylcarbamoyloxy)- 2- butynyl)trimethylammonium ChlorideIBA
02/2020 - 11/2004
3Proteins (Proteins, Gene)FDA Link
01/2019 - 12/2010
35-((2-(6-Amino-9H-purin-9-yl) ethyl) amino)-1-pentanolIBA
10/2014 - 01/2011
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
02/2020 - 05/2013
2Glutamic Acid (Glutamate)FDA Link
12/2019 - 01/2016
2Pharmaceutical PreparationsIBA
10/2014 - 01/2011
2Gabapentin (Neurontin)FDA LinkGeneric
10/2014 - 06/2014
2Adenylyl Cyclases (Adenylyl Cyclase)IBA
08/2014 - 01/2011
2Kainic Acid (Kainate)IBA
09/2013 - 06/2011
2Protein Kinase CIBA
12/2010 - 05/2007
2Streptozocin (Streptozotocin)FDA Link
05/2007 - 11/2004
1NicotineFDA Link
12/2021
1LigandsIBA
08/2020
1Fatty Acid Binding Protein 3IBA
08/2020
1Diazepam (Valium)FDA LinkGeneric
08/2020
1Pilocarpine (Ocusert)FDA LinkGeneric
08/2020
1Pentylenetetrazole (Metrazol)IBA
08/2020
1Dizocilpine Maleate (Dizocilpine)IBA
02/2020
1BicucullineIBA
02/2020
1GABA Receptors (GABA Receptor)IBA
02/2020
1TRPV1 receptorIBA
12/2019
1Capsaicin (Zostrix)FDA Link
12/2019
1Cholinergic Agents (Cholinergics)IBA
01/2019
1Muscarinic Receptors (Muscarinic Acetylcholine Receptor)IBA
01/2019
1Aminobutyrates (Aminobutyric Acid)IBA
01/2019
1BaclofenFDA LinkGeneric
06/2018
1Fragile X Mental Retardation ProteinIBA
01/2018
1BenzodiazepinesIBA
01/2017
1gamma-Aminobutyric Acid (GABA)IBA
01/2017
1Anticonvulsants (Antiepileptic Drugs)IBA
01/2017
1Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
01/2016
1AMPA Receptors (AMPA Receptor)IBA
10/2014
1ColforsinIBA
08/2014
1adenylyl cyclase 1IBA
06/2014
1ZymosanIBA
06/2014
1Histamine (Histamine Dihydrochloride)FDA Link
09/2013
1alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA
06/2011
16-Cyano-7-nitroquinoxaline-2,3-dione (6 Cyano 7 nitroquinoxaline 2,3 dione)IBA
06/2011
1Peptides (Polypeptides)IBA
12/2010
1PlasticsIBA
12/2010
1calphostin CIBA
05/2007
1Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA
05/2007
11- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)IBA
05/2007
1Nerve Growth Factor (NGF)IBA
12/2005
1Brain-Derived Neurotrophic Factor (BDNF)IBA
12/2005
1Lidocaine (Xylocaine)FDA LinkGeneric
12/2005
1Clonidine (ST 155)FDA LinkGeneric
11/2004

Therapy/Procedure

3Ligation
02/2020 - 06/2018
1Intraperitoneal Injections
06/2014
1Spinal Injections
05/2007